Immunotherapy of Disseminated Renal Cell Carcinoma with Transfer Factor

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Abstract
Ten patients with disseminated renal cell carcinoma were treated with transfer factor as an immunostimulant. In 5 patients with metastatic disease evident at the time of initial diagnosis treatment involved removal of the primary tumor followed by transfer factor therapy. Of these patients 3 had a temporary stabilization of metastatic disease. Three patients with recurrent metastatic disease after previous nephrectomy were treated, 2 of whom showed a temporary stabilization of metastatic disease. There were 2 additional patients without clinically evident metastases but at high risk for recurrent disease who were treated and remain free of disease. Five immunologic parameters were used to evaluate the clinical effects of transfer factor. No objective clinical regression was noted in any patient treated with measurable disease.