The use of gamma-radiation-attenuated larvae ofGaigeria pachyscelisRailliet and Henry, 1910, for vaccination in lambs
- 1 December 1978
- journal article
- research article
- Published by Cambridge University Press (CUP) in Journal of Helminthology
- Vol. 52 (4) , 287-290
- https://doi.org/10.1017/s0022149x00005502
Abstract
The results of a vaccination trial in lambs with gamma-irradiated infective larvae ofGaigeria pachyscelisare described. A single percutaneous (P/C) vaccination of lambs with 2000 infective larvae irradiated at 40 Kr induced the development of resistance. The vaccinated lambs successfully resisted a lethal challenge infection of 5000 non-irradiated larvae 3 months later. In the vaccinated lambs, the manifestations of resistance were shown by marked reduction in the worm establishment, development of retarded and functionally sterile worms and absence of clinical signs of hookworm disease after the challenge infection.This publication has 6 references indexed in Scilit:
- Vaccination Against Dictyocaulus Filaria with Irradiated Larvae * *—Some data were presented to the Panel on the Production and Utilization of Radiation Vaccines, IAEA, Vienna, December 16–18, 1963.British Veterinary Journal, 1965
- Effect of X-Irradiation upon the Infective Larvae of Ancylostoma caninum and the Immunogenic Effect in Dogs of a Single Infection with 40 kr-Irradiated LarvaeJournal of Parasitology, 1964