Multiple sequence alignment by consensus
Open Access
- 1 January 1986
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (22) , 9095-9102
- https://doi.org/10.1093/nar/14.22.9095
Abstract
An algorithm for multiple sequenoe alignment is given that matches words of length and degree of mismatch chosen by the user. The alignment maximizes an alignment scoring function. The method is based on a novel extension of our consensus sequence methods. The algorithm works for both DNA and protein sequences, and from earlier work on consensus sequences, it is possible to estimate statistical signifioance.Keywords
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