Activity of erythromycin against chlamydiaein vitroandin vivo, and its use in genital Chlamydia infections

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Abstract
In addition to mycoplasmas, chlamydiae appear to play a significant role as pathogenic agents in abacterial urethritis and in the post-gonorrhoeal syndrome. Forty patients with genital Chlamydia infections associated with subjective and objective signs of urethritis and/or adnexitis were treated for 14 days with 1 g erythromycin stearate twice daily. In 11 patients, the erythromycin sensitivity of the Chlamydia strains was tested, and the MIC values were determined. Two groups with different erythromycin sensitivities were found (0.3 μg/ml, and > 5.0 μg/ml). Therapeutically, no in vivo differences between the two Chlamydia groups were found. In 37 patients, the urethritis/adnexitis was controlled; 2 patients failed to respond and 1 admitted not taking the prescribed erythromycin.