Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II)
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 39 (1) , 74-76
- https://doi.org/10.1007/bf01960636
Abstract
Summary A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 μg/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basic mechanisms underlying renal tubular cystic changes, as well as the mechanisms by which nephrotoxins may mediate renal tubular injury.Keywords
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