Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
- 1 February 1999
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 21 (2) , 213-215
- https://doi.org/10.1038/6002
Abstract
Complex disorders such as diabetes, cardiovascular disease, asthma, hypertension and psychiatric illnesses account for a large and disproportionate share of health care costs, but remain poorly characterized with respect to aetiology. The transmission of such disorders is complex, reflecting the actions and interactions of multiple genetic and environmental factors. Genetic analyses that allow for the simultaneous consideration of susceptibility from multiple regions may improve the ability to map genes for complex disorders, but such analyses are currently computationally intensive and narrowly focused. We describe here an approach to assessing the evidence for statistical interactions between unlinked regions that allows multipoint allele-sharing analysis to take the evidence for linkage at one region into account in assessing the evidence for linkage over the rest of the genome. Using this method, we show that the interaction of genes on chromosomes 2 (NIDDM1) and 15 (near CYP19) makes a contribution to susceptibility to type 2 diabetes in Mexican Americans from Starr County, Texas.Keywords
This publication has 14 references indexed in Scilit:
- Allele-Sharing Models: LOD Scores and Accurate Linkage TestsAmerican Journal of Human Genetics, 1997
- Mutations in the Hepatocyte Nuclear Factor-1α/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDMDiabetes, 1997
- Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.Journal of Clinical Investigation, 1997
- Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null AllelesCell, 1997
- Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.Human Heredity, 1997
- Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish familiesNature Genetics, 1996
- A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2Nature Genetics, 1996
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 1995
- Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes MellitusNew England Journal of Medicine, 1993
- On the statistical determination of major gene mechanisms in continuous human traits: Regressive modelsAmerican Journal of Medical Genetics, 1984