FAILURE OF METOCLOPRAMIDE TO INFLUENCE LH, FSH AND TSH SECRETION OR THEIR RESPONSES TO RELEASING HORMONES
- 1 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 92 (4) , 640-647
- https://doi.org/10.1530/acta.0.0920640
Abstract
I.v. metoclopramide (MET, 10 mg) induced a brisk PRL [prolactin] response with a mean .+-. SE peak of 85.3 .+-. 7.7 ng/ml maximal at 30 min [in humans]. L-Dopa, but not atropine pretreatment, attenuated the PRL response to MET. The antidopaminergic properties of MET mediate PRL secretion. MET did not influence basal levels of TSH [thyrotropin], LH [luteinizing hormone] or FSH [follicle stimulating hormone]. Neither did it affect their response to the respective releasing hormones. Dopaminergic blockade induced by i.v. MET, does not influence the secretion of the pituitary glycoprotein hormones.This publication has 13 references indexed in Scilit:
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