SYSTEMIC EVALUATION OF SJÖGREN-LIKE SYNDROME AFTER BONE MARROW TRANSPLANTATION IN MAN
- 1 May 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 43 (5) , 677-679
- https://doi.org/10.1097/00007890-198705000-00015
Abstract
A systematic evaluation of Sjögren-like syndrome (SLS) was performed in 68 bone marrow transplant (BMT) recipients (60 allogeneic and 8 syngeneic recipients). At day 100, the patients underwent clinical evaluation, functional salivary scintigraphy, and lip biopsy. If any findings were abnormal, the examinations were repeated annually for 3 years. Twenty-two patients with SLS and extensive chronic graft-versus-host disease (CGVHD) had abnormal scintiscan and lip biopsy at day 100. Marked keratoconjunctivitis sicca and xerostomia developed between 12 and 24 months after BMT and, thereafter, progressively decreased. Twenty-seven irradiated recipients (7 syngeneic and 20 allogeneic recipients without CGVHD) had isolated xerostomia and disturbed scintiscan but normal biopsy. Seven other patients with limited CGVHD had a lymphocytic infiltrate on lip biopsy but no SLS and a normal scintiscan. Schirmer's test, functional salivary scintigraphy, and lip biopsy allowed us to distinguish SLS from radiotherapy sequelae. As early as day 100, these 3 tests have a predictive value for SLS, one of the criteria for extensive CGVHD.This publication has 13 references indexed in Scilit:
- Oral and ophthalmic pathology of graft versus host disease in man: Predictive value of the lip biopsyPublished by Elsevier ,2007
- Radiosensitivity in Fanconi anaemia: application to the conditioning regimen for bone marrow transplantationBritish Journal of Haematology, 1983
- DISORDERED SALIVARY IMMUNOGLOBULIN SECRETION AND SODIUM TRANSPORT IN HUMAN CHRONIC GRAFT-VERSUS-HOST DISEASETransplantation, 1983
- Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppressionBlood, 1981
- Chronic graft-versus-host syndrome in manThe American Journal of Medicine, 1980
- An evaluation of salivary scintigraphy in sögren's syndromeArthritis & Rheumatism, 1979
- Chronic graft versus host disease: A syndrome of disordered immunityThe American Journal of Medicine, 1979
- CHRONIC CUTANEOUS GRAFT VERSUS HOST DISEASE IN MAN1978
- Scleroderma, Sjögren-like Syndrome, and Chronic Graft-Versus-Host DiseaseAnnals of Internal Medicine, 1977
- Sjögren-Type Syndrome After Allogeneic Bone-Marrow TransplantationAnnals of Internal Medicine, 1977