PRODUCTION IN MICE OF TOLERANCE TO THE TOXIC MANIFESTATIONS OFCANDIDA ALBICANS

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Abstract
Hasenclever, H. F. (National Institutes of Health, Bethesda, Md.)and William O. Mitchell. Production in mice of tolerance to the toxic manifestations ofCandida albicans. J. Bacteriol.84:402–409. 1962. — Lethal toxic manifestations ofCandida albicansin mice were demonstrated by the intravenous injection of 107viable yeast cells. Untreated control animals had an average survival time of 4.5 to 10 hr after challenge. No multiplication ofC. albicanscould be demonstrated in the tissues of untreated infected controls 12 hr after challenge. Mice infected ip withC. albicans6 days before iv challenge survived for periods three to four times longer than controls. Mice previously infected with other fungi also demonstrated tolerance to the toxicity ofC. albicans. Coccidioides immitisandC. stellatoideawere especially effective. High-titer rabbit antiserum to viableC. albicansyeast cells was not protective. Studies of total and differential peripheral leukocytes indicated that mice in the tolerant state demonstrated a slight granulocytosis. Direct evidence of the protective effect of the granulocytic response was not shown

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