Mesure de la fonction glomérulaire par la décroissance plasmatique d’une substance analogue à I’inuline (Polyfructosan-S)

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Abstract
Forty min after stopping intravenous perfusion of Polyfructosan and equilibration being thus attained, the fall of plasma concentrations shows an exponential relationship with time: Ct2=Ct1e-[eta] [center dot] [DELTA] t. The slope [eta] of the straight line formed by the logarithms of successive plasma levels is the fraction of a "functional" extracellular volume cleared per time unit: [image] The present experiments show an excellent correlation (r 0.9) between this constant, called relative clearance, and the conventional renal clearance measured during continuous perfusion; this, in 32 subjects with normal or impaired renal function and no fluid retention. This correlation is much higher than the one obtained between conventional clearance and routine endogenous creatinine clearance. Such results confirm the possiblity of a simple test without urine collection and without continuous perfusion, for the estimation of glomerular filtration rate. However, after a single injection of Polyfructosan, preliminary observations show that an equilibration period of 70 min is needed in order to obtain an exponential fall of plasma concentration.

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