NEUROFIBRILLARY TANGLES OF ALZHEIMERS-DISEASE - AN IMMUNOHISTOCHEMICAL STUDY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 17  (1) , 89-96
Abstract
The reactivity of [human] neurofibrillary tangles (NFT) of Alzheimer''s disease with several antisera was studied by immunocytochemistry. They were heavily labeled by an antiserum prepared against isolated NFT; the latter also remained stainable by Bodian-Ag method. Some NFT were labeled on vibratome sections by an antimicrotubular protein but remained able to be counterstained by Congo Red, suggesting this labeling could demonstrate material trapped in NFT. The immunoelectron labeling shows that the abnormal filaments, straight as well as twisted, are the only structures recognized by the anti-NFT serum. This labeling was prevented only by pre-incubation with fractions enriched in NFT, confirming the presence of unique antigenic determinants in the latter.