Effects of in vivo administration of G–CSF on neutrophil functions in healthy volunteers

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Abstract
The aim of the present study was to investigate the in vivo effects of granulocyte colony-stimulating factor (G–CSF) on neutrophil (PMN) function. G–CSF was administered once daily as s.c. injection for 6 d (d1–6) to healthy male volunteers. PMN migration (modified Boyden chamber), chemiluminescence (CL), adherence to nylon fibers and phagocytosis of IgG- and IgG-C3-coated particles were investigated before (d1), during (d2, d5) and 3 wk after G–CSF 7.5–10 μg/kg/d (n=12). PMN surface expression of adhesion- and Fcγ-receptors was measured on d1, d5, d8 and 3 wk after G–CSF 3–5 μg/kg (n=12). Results obtained after G–CSF were compared to baseline using Wilcoxon's signed rank test. G–CSF induced PMNs showed a significantly (pin vivo does not stimulate the respiratory burst.

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