PHOSPHORYLCHOLINE ANTIGENS FROM NIPPOSTRONGYLUS-BRASILIENSIS .1. ANTI-PHOSPHORYLCHOLINE ANTIBODIES IN INFECTED-RATS AND LOCATION OF PHOSPHORYLCHOLINE ANTIGENS

  • 1 January 1979
    • journal article
    • research article
    • Vol. C130  (6) , 879-+
Abstract
The anti-phosphorylcholine (PC) antibody [Ab] synthesis was investigated in the rat after infection with the nematode N. brasiliensis. Serum Ig[immunoglobulin]M and IgG Ab were demonstrated from day 2 or 3 post-infection. Intestinal IgA Ab synthesis began shortly after the worms reached the intestine. Antigens containing PC were located with the fluorescent Ab technique in L3 infective larvae, adult worms and eggs of the parasites. They were always bound to internal structures such as intestinal tract or gonads. The anti-PC Ab synthesis apparently resulted from the release of PC antigens by the parasite (moulting fluids, excretion, secretion or breakage products).