Some Critical Considerations on the Use of the Nomifensine Test in the Hyperprolactinaemic Syndrome

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Abstract
Nomifensine was recently proposed as a dynamic test to discriminate tumoral from functional hyperprolactinemia. This test was performed in 9 subjects with radiological signs of sellar alteration and in 6 with no signs of pituitary lesion. Adopting the criterion reported in the previous study, the test was considered positive in 2 subjects of the 1st group and in 2 subjects of the 2nd group. The ability of this test to discriminate subjects with tumorous or nontumorous hyperprolactinemia still appears debatable.