Alterations in Pathogenesis of Experimental Lymphocytic Choriomeningitis Caused by Prepassage of the Virus Through Heterologous Host

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Abstract
Summary: Three strains of the virus of lymphocytic choriomeningitis were maintained by serial passages through mice and guinea-pigs. The substrains thus obtained possessed marked meningo-encephalotropism but differed in viscerotropic affinities. The meningo-encephalotropism was maintained by both species. Viscerotropism was lost in the mouse, but restored or imparted to the virus by the guinea-pig. Significant alterations in the pathogenesis of experimental disease were contingent upon the differences in viscerotropic affinities of the substrains.