FACTORS AFFECTING THE UPTAKE OF WATER BY FROGS WHEN INJECTED WITH EXTRACT OF THE POSTERIOR HYPOPHYSIS

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Abstract
Injs. of pituitary (post. lobe) extract B.P. 1932 into Rana pipiens immersed in water produced a 10-25% gain in wt. of the animals within a few hrs. This reaction was not affected by difference in sp. within the genus Rana, body wt., sex, vol. of water in the frog bath and the site or mode of inj. Adding the extract to the frog bath had no effect. The extent of the reaction varied inversely as the intensity of light and the duration varied inversely as the temp. Conc. of NaCl, KCl or Na phosphates in the bath greater than 0.4% inhibited the reaction and the optimum pH was 7.0, with little difference between pH 6.0 and 8.0. The response varied approximately as the dosage until a maximum was reached and pitocin contained more of the hormone than pitressin.

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