Survival and Growth of Human Tissues Transplanted to Hamster Cheek Pouch

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Abstract
Investigations of the mechanisms of tumor growth and metastasis have been hampered by the lack of suitable methods of isolation and subcultivation of human neoplastic cells. The cheek pouch of the golden hamster (Mesocricetus auratus) was shown to be a excellent site for transplants of induced homologous sarcomas, permitting quantitative measurements of growth rates, microscopic study of vascularization, and maintenance by serial passage of the neoplasm. The present paper deals with the technic and the results obtained from the transplantion of tissues from 50 cancerous patients into the cheek pouches of golden hamsters.