Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women
Open Access
- 13 May 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 279 (18) , 1445-1451
- https://doi.org/10.1001/jama.279.18.1445
Abstract
MILLIONS OF postmenopausal women currently face a difficult dilemma: whether they should or should not take estrogen replacement. Estrogen use may protect against osteoporosis and heart disease, but may increase the risks of breast and endometrial cancers.1 Thus, there could be serious consequences in choosing to take estrogen, or in choosing not to take estrogen. Nearly half of postmenopausal women who begin hormone treatment discontinue use within 1 year.2 This is believed to be because of lingering concerns they may have about the long-term hazards of this treatment or unacceptable adverse effects such as vaginal bleeding and breast tenderness.Keywords
This publication has 16 references indexed in Scilit:
- Raloxifene Inhibits Aortic Accumulation of Cholesterol in Ovariectomized, Cholesterol-Fed RabbitsCirculation, 1997
- Structure−Activity Relationships of Selective Estrogen Receptor Modulators: Modifications to the 2-Arylbenzothiophene Core of RaloxifeneJournal of Medicinal Chemistry, 1997
- A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal womenJournal of Bone and Mineral Research, 1996
- Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic AcidJNCI Journal of the National Cancer Institute, 1996
- Longitudinal Patterns and Correlates of Hormone Replacement Therapy Use in Middle-aged WomenAmerican Journal of Epidemiology, 1994
- Risk of endometrial cancer after tamoxifen treatment of breast cancerThe Lancet, 1994
- Cardiac and Thromboembolic Morbidity Among Postmenopausal Women With Early Stage Breast Cancer in a Randomized Trial of Adjuvant TamoxifenJNCI Journal of the National Cancer Institute, 1993
- Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast CancerNew England Journal of Medicine, 1992
- Effects of Postmenopausal Estrogen Replacement on the Concentrations and Metabolism of Plasma LipoproteinsNew England Journal of Medicine, 1991
- Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. The Scottish Breast Cancer Committee.BMJ, 1991