A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells
- 1 December 1988
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 37 (24) , 4661-4669
- https://doi.org/10.1016/0006-2952(88)90335-8
Abstract
No abstract availableThis publication has 26 references indexed in Scilit:
- The toxicity and mutagenicity of the anti-tumour drug 5-aziridino-2, 4-dinitrobenzamide (CB1954) is greatly reduced in a nitroreductase-deficient strain of E. coliMutagenesis, 1987
- CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cellsBiochemical and Biophysical Research Communications, 1986
- CB 1954 revisitedCancer Chemotherapy and Pharmacology, 1986
- CB 1954 revisitedCancer Chemotherapy and Pharmacology, 1986
- Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)Biochemical Pharmacology, 1980
- Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4‐amino‐5‐imidazolecarboxamideInternational Journal of Cancer, 1972
- The differential response of resistant and sensitive strains of Escherichia coli to the cytotoxic effects of 5-aziridino-2,4-dinitrobenzamide (CB 1954)Chemico-Biological Interactions, 1971
- Quantitative aspects of the repair of alkylated DNA in cultured mammalian cellsChemico-Biological Interactions, 1971
- Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumourInternational Journal of Cancer, 1971
- 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256Biochemical Pharmacology, 1969