RENAL FUNCTION IN IDIOPATHIC RESPIRATORY DISTRESS SYNDROME

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Abstract
Renal function was studied in 11 pre-term infants with idiopathic respiratory distress syndrome (IRDS) grade 1 according to Prod''hom''s criteria. As a reference 16 healthy pre-term infants were studied. The groups did not differ with regard to mean gestational age (GA) and mean postnatal age (PNA). The studies were performed twice, 1st at a PNA of 33-37 h and then at 132-148 h. GFR [glomerular filtration rate] and CPAH [p-aminohippurate clearance] were determined with the single injection technique and the ability to excrete Na+ was determined following an oral Na+ load. GFR was higher in IRDS infants at the 1st investigation and slightly lower in IRDS infants at the 2nd investigation. The GFR correlated to the lowest recorded PaO2 [arterial O2 partial pressure] (r = 0.45) in IRDS infants. CPAH was similar in IRDS and controls at the 1st and lower in IRDS infants at the 2nd investigation. The urinary Na+ excretion was significantly higher in IRDS infants. Treatment with digitalis was in part responsible for the high urinary Na+ excretion. The IRDS infants had a higher Na+ and glucose intake than the control infants. This higher intake is in part responsible for the relatively high GFR and urinary Na+ excretion in the IRDS infants.