Prevention of Type 2 Diabetes

1 January 1999

journal article
review article
Published by Springer Nature in Drugs

Vol. 58 (1) , 71-73
https://doi.org/10.2165/00003495-199958001-00015

Abstract

Metformin lowers moderate (nondiabetic) fasting hyperglycaemia in individuals at risk for type 2 diabetes without causing hypoglycaemia. In addition, it has demonstrated favourable action on several cardiovascular risk factors that are often present in these individuals: it favours the maintenance of diet-induced weight loss and its associated improvement in fibrinolysis; and it lowers plasma concentrations of fasting insulin, total and low density lipoprotein-cholesterol, free fatty acids, and of two markers of endothelial damage--tissue plasminogen activator antigen and von Willebrand factor. These effects together with the good tolerability profile of the drug position metformin as a first-line agent for the prevention of type 2 diabetes.

Keywords

This publication has 16 references indexed in Scilit:

Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones
Published by Elsevier ,2016
Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity.
Diabetes Care, 1998
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
1998
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
BMJ, 1998
Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease
Journal of Internal Medicine, 1996
Metformin
New England Journal of Medicine, 1996
Glycemic Control and the Risk for Coronary Heart Disease in Patients with Non-Insulin-dependent Diabetes Mellitus: The Finnish Studies
Annals of Internal Medicine, 1996
Hyperglycemie and Microvascular and Macrovascular Disease in Diabetes
Diabetes Care, 1995
Metformin and metoprolol CR treatment in non-obese men
Journal of Internal Medicine, 1994
Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
JAMA, 1990