Quinacrine: Mechanisms of Antimalarial Action
- 31 July 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3944) , 492-493
- https://doi.org/10.1126/science.169.3944.492
Abstract
Two new interesting modes of action of quinacrine have been discovered. The first concerns a dose-related inhibition of uptake of [8-3H] adenosine into host cells of parasitized blood. Second, the drug inhibits the incorporation of tritiated adenosine triphosphate primarily into RNA but also into DNA of the erythrocyte-free malarial parasite Plasmodium berghei.Keywords
This publication has 15 references indexed in Scilit:
- A fluorescent complex between ethidium bromide and nucleic acids: Physical—Chemical characterizationPublished by Elsevier ,2004
- Studies concerning the mechanism of action of antimalarial drugs—: Inhibition of the incorporation of adenosine-8-3H into nucleic acids of Plasmodium bergheiBiochemical Pharmacology, 1969
- Acridine Orange Staining and Fluorescence of Nucleic Acids in Plasmodia and Associated Host ErythrocytesStain Technology, 1969
- Purine and Pyrimidine Synthesis by the Avian Malaria Parasite, Plasmodium lophurae*The Journal of Protozoology, 1968
- The interaction of aminoacridines with nucleic acidsBiopolymers, 1968
- Studies on the uptake of nucleic acid precursors into cells in tissue cultureBiochimica et Biophysica Acta (BBA) - General Subjects, 1968
- Automated systems for the fluorometric determination of nucleic acids by the ethidium bromide techniqueAnalytical Biochemistry, 1968
- Quinacrine (Atebrin): Mode of ActionScience, 1967
- Chloroquine: Mode of ActionScience, 1966
- Kompetitive Hemmung der katalysierten Adenosindiffusion als Mechanismus der coronarerweiternden Wirkung eines Pyrimido-pyrimidin-DerivatesPflügers Archiv - European Journal of Physiology, 1964