224Ra and 226Ra experimentally induced dental changes in rats

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Abstract
Sprague-Dawley rats received intragastrically a single dose of 226Ra or 224Ra once weekly for 21 wk. During this period the animals of both groups were thus exposed to comparable doses. After 12 wk, a shortening of the maxillary incisors was observed; this progressed during the course of the 55 wk experiment. Radiologically, a loss of pulpal transparency and an apical irregular opacity in the maxillary incisors were demonstrable. Histologically, dyplastic changes of the maxillary incisors and multiple resorptions at the cemento-enamel junction of the molar were seen. The observed alterations were more pronounced in the 226Ra group than in the 224Ra treated group. The experimentally induced resorptions are comparable to those observed in patients who had incorporated 224Ra or 226Ra. Clinical, radiological, histological, .gamma.-spectrometrical and autoradiographical findings, as well as dose-estimations, are described.

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