Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system
- 1 June 1998
- journal article
- Published by Springer Nature in Nature Biotechnology
- Vol. 16 (6) , 553-555
- https://doi.org/10.1038/nbt0698-553
Abstract
We have developed a tetracycline-regulatable adenoviral transfection system that mediates efficient long-term transfer of genes into neuronal cells in vivo. This system allows gene expression to be switched on, then off, and back on again simply by administering or removing doxycycline from the animals' drinking water. This regulatable adenoviral vector system should be of value in behavioral studies and in vivo studies of neuronal gene function, and may further the development of effective gene therapy strategies in the brain.Keywords
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