The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster.
- 17 January 1995
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 92 (2) , 612-616
- https://doi.org/10.1073/pnas.92.2.612
Abstract
The period protein (PER) is a essential component of the circadian clock in Drosophila melanogaster. Although PER-containing pacemaker cells have been previously identified in the brain, the neuronal network that comprises the circadian clock remained unknown. Here it is shown that some PER neurons are also immunostained with an antiserum against the crustacean pigment-dispersing hormone (PDH). This antiserum reveals the entire arborization pattern of these pacemaker cells. The arborizations of these neurons are appropriate for modulation of the activity of many neurons and they might interact with PER-containing glial cells. A putative physiological role of PDH in the circadian system is discussed.Keywords
This publication has 25 references indexed in Scilit:
- A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the drosophila nervous systemNeuron, 1994
- Daily and circadian rhythms of synaptic frequency in the first visual neuropile of the housefly’s ( Musca domestica L.) optic lobeProceedings Of The Royal Society B-Biological Sciences, 1993
- PAS is a dimerization domain common to Drosophila Period and several transcription factorsNature, 1993
- The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expressionNeuron, 1991
- Monoclonal antibodies recognize localized antigens in the eye and central nervous system of the marine snail Bulla gouldiana.Journal of Histochemistry & Cytochemistry, 1991
- Peptide‐immunocytochemistry of neurosecretory cells in the brain and retrocerebral complex of the sphinx moth Manduca sextaJournal of Comparative Neurology, 1991
- Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levelsNature, 1990
- Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual systemNeuron, 1988
- Spatial and temporal expression of the period gene in Drosophila melanogaster.Genes & Development, 1988
- Cobalt-immunocytochemical identification of peptidergic neurons inCalliphora innervating central and peripheral targetsJournal of Neurocytology, 1983