Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
- 1 February 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 343 (6258) , 536-540
- https://doi.org/10.1038/343536a0
Abstract
Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.Keywords
This publication has 37 references indexed in Scilit:
- In situ localization of the per clock protein during development of Drosophila melanogaster.Molecular and Cellular Biology, 1988
- Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual systemNeuron, 1988
- Mutations and Molecules Influencing Biological RhythmsAnnual Review of Neuroscience, 1988
- Spatial and temporal expression of the period gene in Drosophila melanogaster.Genes & Development, 1988
- Genetics and molecular biology of rhythmsBioEssays, 1987
- Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clockNature, 1987
- A family of unusually spliced biologically active transcripts encoded by a Drosophila clock geneNature, 1987
- Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster.Proceedings of the National Academy of Sciences, 1987
- Mosaic analysis of a Drosophila clock mutantMolecular Genetics and Genomics, 1983
- Clock Mutants of Drosophila melanogasterProceedings of the National Academy of Sciences, 1971