Antimalarial Activities of Polyhydroxyphenyl and Hydroxamic Acid Derivatives
- 1 September 1998
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 42 (9) , 2456-2458
- https://doi.org/10.1128/aac.42.9.2456
Abstract
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum . Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.Keywords
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