Sodium Hydroxide Decontamination of Creutzfeldt–Jakob Disease Virus

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Abstract
To the Editor: A useful method of chemical (sodium hydroxide) decontamination of the virus of Creutzfeldt–Jakob disease (CJD) has been successfully tested in our laboratory. In view of the mounting concern of medical and paramedical personnel about contact with patients with CJD or their tissues, we have attempted to develop practical decontamination procedures for laboratory and hospital use.In an earlier report,1 we documented the effectiveness of a one-hour exposure to 0.5 per cent sodium hypochlorite (1:10 dilution of household bleach) for inactivation of a guinea pig–adapted strain of CJD virus in tissue suspensions that contained about the same concentration . . .