Fate of ochratoxin a in goats

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Abstract
The fate of ochratoxin A (OA) was studied in goats given a single oral dose of 3H-OA (0.5 mg/kg). More than 90% of the radioactivity was excreted in 7 days and the majority (53%) was found in feces. Urine, milk and serum combined 38, 6 and 2.26% of the activity, respectively. The radioactivity in the liver and kidney 6 h after feeding amounted to 1.5 and 0.5% of the total dose administered, respectively. Subsequent fractionation of liver and kidney homogenates revealed that microsomes, ribosomes and post-ribosomal supernatant fractions contained most radioactivity. TLC analyses revealed 2 additional radioactive spots with Rf values and fluorescent characteristics different from OA, O.alpha. and 4-OH-OA. OA was found as the unaltered molecule in feces but the metabolites were primarily found in urine and milk. Less than 0.03% of free OA was found in milk during 7 day.