Synthesis and properties of the first all‐aza analogue of a biologically active peptide
- 1 May 1995
- journal article
- review article
- Published by Wiley in Journal of Peptide Science
- Vol. 1 (3) , 201-206
- https://doi.org/10.1002/psc.310010307
Abstract
The synthesis of the first all‐aza‐amino acid analogue (2) of a peptidic renin inhibitor is described. The X‐ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.Keywords
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