Association of Benzo[a]Pyrene-Diol-Epoxide-Deoxyribonucleic Acid (BPDE-DNA) Adduct Level with Aging in Male Smokers and Nonsmokers

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Abstract
We used our new flow cytometric method to measure benzo[a]pyrene-diol-epoxide-deoxyribonucleic acid adduct levels in peripheral lymphocytes from healthy male smokers and nonsmokers. Smokers who had pack-years of 20 or more had significantly higher mean benzo[a]pyrene-diol-epoxide-deoxyribonucleic acid adduct levels than nonsmokers. In smokers, the adduct levels were correlated significantly with age, years of smoking, and pack-years, whereas daily tobacco consumption was not correlated with adduct levels. We also found a positive relationship between age and benzo[a]pyrene-diol-epoxide-deoxyribonucleic acid adduct levels in nonsmokers. Passive exposure to tobacco smoke was not associated with adduct levels. The results of our study indicate that benzo[a]pyrene-diol-epoxide-deoxyribonucleic acid adduct levels may be closely related to aging and that tobacco smoking–as well as other environmental factors–may play a role in the benzo[a]pyrene-diol-epoxide-deoxyribonucleic acid adduct formation.

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