Development of a Self Compressed Column System

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Abstract
In the course of this work a novel HPLC column system has been developed. The system consists of a flexible-walled column made of Teflon tubing and a compression chamber through which the eluent is pumped. The column is placed in the chamber and compressed by a hydraulic pressure caused by the column back pressure. The performance of this system was characterized using commercially available C18 packing materials. The system is particularly useful for characterization or application of new stationary phases which are not commercially available.