A New Fluorescent Chemosensor for Copper Ions Based on Tripeptide Glycyl−Histidyl−Lysine (GHK)
- 26 September 2001
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (21) , 3277-3280
- https://doi.org/10.1021/ol0101638
Abstract
[structure: see text]. A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.Keywords
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