Evidence for Impaired Glucose Tolerance in Uncomplicated Psoriasis

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Abstract
In a small but highly selected series of patients with uncomplicated psoriasis we found four patients with abnormal results from an oral glucose tolerance test (OGTT) and 13 of 34 patients (38%) of those with a normal OGTT value who had an abnormal cortisone glucose tolerance test (CGTT) result. This degree of abnormal glucose tolerance mimics the frequency of impaired tolerance in the close relatives of known diabetics. While our findings are preliminary, they are unique in that only uncomplicated psoriatics were studied. On the basis of our findings, we believe that the clinician would be well advised to evaluate each psoriasis patient for diabetes and to be alert to diabetes developing when selecting treatment for, and in observing, the patient with psoriasis.

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