Pharmacokinetic studies of theophylline in horses
- 1 March 1985
- journal article
- research article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 8 (1) , 76-81
- https://doi.org/10.1111/j.1365-2885.1985.tb00927.x
Abstract
The pharmacokinetics of theophylline [used as a bronchodilator] were determined in Standardbred trotters after single i.v. and oral administration. A bi-exponential equation was fitted to the i.v. data and a tri-exponential equation to the oral data. The biological half-life of theophylline was 14.8 h, the volume of distribution 1.02 l/kg and the total plasma clearance 0.86 ml/kg/min. The oral absorption of the drug was complete (bioavailability 108%) and rapid (absorption half-life 0.4 h).This publication has 6 references indexed in Scilit:
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