HYPOTENSIVE ACTION OF SYNTHETIC FRAGMENTS OF PARATHYROID-HORMONE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 216  (3) , 567-571
Abstract
Parathyroid hormone (PTH) and its N-terminal 1-34 fragment were hypotensive in dogs. Synthetic bovine [b] PTH fragments containing the N-terminal amino acids 1-34, 24-34, 24-28 and 25-27 [bPTH-(1-34), bPTH-(24-34), bPTH-(24-28) and bPTH-(24-27)] were synthesized and tested for hypotensive activity in dogs. bPTH-(1-34) is the most potent of these. The tripeptide is ineffective at doses as high as 2 mg/kg. bPTH-(24-34) and bPTH-(24-28) exhibited hypotensive activity but were less effective than bPTH-(1-34). A decrease in chain length decreased the hypotensive activity. The maximum responses produced by bPTH-(1-34) was greater than that of either bPTH-(24-34) or bPTH-(24-28). The maximum responses, however, of bPTH-(24-34) and bPTH-(24-28) were similar. Another striking difference between bPTH-(1-34) and the other 2 effective fragments was the duration of action. Whereas the action of bPTH-(1-34) at ED50 lasted for up to 6 min, the action of bPTH-(24-34) and bPTH-(24-28) lasted for less than 1 min. The hypotensive effect of these 3 bPTH fragments was not affected by propranolol, phentolamine, atropine, promethazine or cimetidine. In the perfused rat hindlimb, bPTH-(24-28) produced log dose-related sustained vasodilation.

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