The Oxidative Metabolism of Trypanosoma Lewisi from Salicylate Treated Infected White Rats

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Abstract
Experiments were carried out with trypanosomes of 4 population types: 4N and 9N were trypanosomes from untreated rats with 4- and 9-day infections; 4S and 9S were from rats that received 45 mg sodium salicylate per os daily for the 4 and 9 days, respectively. The trypanosomes from treated and untreated rats showed that the typical lower O2 uptake of the reproducing populations was maintained in trypanosomes obtained from sali-cylate-treated infected rats. There was no evidence to support any in vitro effect of sodium salicylate upon trypanosomes not previously exposed to salicylate in the rat. Negative results were obtained in the series of experiments attempting to demonstrate an in vitro effect of immune serum upon O2 uptake by the addition of immune serum to trypanosomes respiring in Warburg flasks. Under anaerobic conditions the amount of CO2 produced by infections from salicylate-treated and untreated infected rats was essentially the same. Findings on the change in O2 uptake in the normal infections corroborated those of Moulder (1948). However, a corresponding change in glucose consumption could not be shown.