CORTISONE INDUCED MODIFICATIONS IN THE DEVELOPMENT OF THE CHICK EMBRYO1

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Abstract
Single doses of cortisone acetate, applied to the allantoic vesicle or chorioal-lantoic membrane of the chick embryo, on the 3rd to 8th day of incubation produce a variety of disturbances in the embryo depending on the dosage and the time of injection. Cortisone is relatively more toxic to the early embryo, and in those that survive, weight inhibition, defects in the facial bones and tibia, and exteriorized viscera occur. In embryos treated at a later stage, weight inhibition is more severe, but the defects in the facial bones are no longer present, feather inhibition is marked, and there are major disturbances in osseous development. The susceptibility of various organs in the chick embryo to cortisone is specific, and varies with their stage of development.