Bactericidal action of peptide antibiotic AS-48 against Escherichia coli K-12
- 1 February 1989
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 35 (2) , 318-321
- https://doi.org/10.1139/m89-048
Abstract
Peptide antibiotic AS-48 exerts a bactericidal mode of action on exponential cultures of Escherichia coli K-12 through a multi-hit kinetics interaction. AS-48 causes a parallel and gradual cessation of all biosynthetic pathways monitored (protein, RNA, DNA, and cell wall synthesis), the rate of incorporation of labeled precursors, the rate of O2 consumption, and cell growth. These effects have been attributed to alterations of cytoplasmic membrane functions.This publication has 4 references indexed in Scilit:
- Identification and location of l-glycerate, an unusual acyl substituent in gellan gumCarbohydrate Research, 1986
- Characterization and partial purification of a broad spectrum antibiotic AS-48 produced by Streptococcus faecalisCanadian Journal of Microbiology, 1986
- Polymyxin and Related Peptide AntibioticsAnnual Review of Biochemistry, 1977
- ANTIBACTERIAL ACTIVITY ASSOCIATED WITHLACTOBACILLUS ACIDOPHILUSJournal of Bacteriology, 1959