Immunoglobulin G Heavy-Chain Allotypes as Possible Genetic Markers for Human Cancer23

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Abstract
Serum samples from 343 unrelated, healthy Japanese, 194 hepatitis B surface antigen (HBsAg)-positive healthy carriers, 96 patients with primary hepatoma, 91 patients with lung cancer, 94 patients with breast cancer, and 87 patients with gastric cancer were examined for IgG heavy-chain allotypes (Gm). The Gm phenotypes of the sera from patients with breast cancer exhibited a distribution similar to that of the normal controls. However, compared to that of normal controls, the Gm pheno-type (1,2,21,13,15,16) was significantly increased in the patients with primary hepatoma (χ21 = 15.12, corrected Px21= 10.97, corrected P1,2,21 was significantly increased in the patients with primary hepatoma (x21 = 22.34, corrected P1,2,21 in primary hepatoma was also significant compared to that of HBsAg-positive healthy carriers (x21=9.25, corrected P<0.05).