Cardiac Dilatation Without Hypertrophy from Reduced Ambient Pressure in Rats

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Abstract
Short exposures of rats to greatly reduced ambient pressure after explosive decompression was found to result in cardiac dilatation. The dilatation, determined roentgenographically, was seen to persist for two or three days. Some rats were submitted to one long exposure, while others were repeatedly subjected to short exposures. Sacrifice of the rats sufficiently long after exposure to permit cardiac hypertrophy to develop revealed no evidence of it as determined from heart weightbody weight ratios.