METHOTREXATE WITH CITROVORUM FACTOR RESCUE FOR GESTATIONAL TROPHOBLASTIC NEOPLASMS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (1) , 93-96
Abstract
Patients [35] with nometastatic gestational trophoblastic neoplasms and 3 patients with metastatic gestational trophoblastic neoplasms were treated with methotrexate and citrovorum factor rescue. The antecedent pregnancy was molar in all patients. The known histologic diagnosis in 34 patients was hydatidiform mole and choriocarcinoma in 3. Up to March, 1977, the duration of remissions ranged from 1-21 mo. Complete and sustained remission was achieved in 91% of patients with nonmetastatic disease and 2 of the 3 patients with metastases, without evidence of marrow or hepatic and with substantially reduced epithelial toxicity. Response to treatment and the number of courses required to achieve remission were determined on the basis of the human chorionic gonadotropin response as measured by the .beta. subunit radioimmunoassay.