ABSENCE OF INSULIN RESISTANCE IN 4 CASES OF MILD JUVENILE DIABETES
- 1 March 1975
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 64 (2) , 248-252
- https://doi.org/10.1111/j.1651-2227.1975.tb03829.x
Abstract
Four children with a mild non-insulin-requiring diabetes were studied. They had no insulin response at intravenous glucose tolerance test. When insulin was infused at a rate which simulated a normal early insulin response to intravenous glucose, blood glucose decreased to the same extent as it did in healthy subjects. When a normal early insulin response was simulated during the intravenous glucose tolerance test, the glucose assimilation rate was normalized. These results suggests that a peripheral resistance to insulin is unlikely in mild juvenile diabetes, and that the primary defect is a deficient release of insulin.Keywords
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