Anthrax toxin rafts into cells
Open Access
- 3 February 2003
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 160 (3) , 295-296
- https://doi.org/10.1083/jcb.200301032
Abstract
Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway.Keywords
This publication has 11 references indexed in Scilit:
- Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent processThe Journal of cell biology, 2003
- 2001: a year of major advances in anthrax toxin researchTrends in Microbiology, 2002
- Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigenProceedings of the National Academy of Sciences, 2002
- Endocytosis Via CaveolaeTraffic, 2002
- Identification of the cellular receptor for anthrax toxinNature, 2001
- A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen TargetingThe Journal of Experimental Medicine, 1999
- Membrane microdomains and caveolaeCurrent Opinion in Cell Biology, 1999
- Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane ComponentsThe Journal of cell biology, 1998
- Functional rafts in cell membranesNature, 1997
- Crystal structure of the anthrax toxin protective antigenNature, 1997