Rapid Spectrophotometric Assay of Cephradine and its Dosage Forms
- 1 June 1991
- journal article
- pharmaceutical analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 24 (6) , 971-978
- https://doi.org/10.1080/00032719108054367
Abstract
A new spectrophotometric method to determine cephradine based on its reaction with acetylacetone-formaldehyde reagent (pH 4.3) is proposed. The yellow chromophore shows an absorption maxima at 400 nm, having a molar absorptivity coefficient of 2.59. 103 L mol−1 cm−1. Optimization of the reaction conditions has been investigated. Obediance to Beer's law (0–110 mog per ml) permitted the assay of cephradine in its dosage forms. The method has been compared with the official method and found to be simple, artwrate (t-test) and reproducible (F-test).Keywords
This publication has 4 references indexed in Scilit:
- Analytical investigations of β-lactam antibiotics in pharmaceutical preparations—II. Spectrophotometric determination of cephalexin, cephradine, ampicillin and amoxycillin using copper(II) acetate as a completing agentJournal of Pharmaceutical and Biomedical Analysis, 1988
- Rapid microbiological pH assay for the determination of cephradine in pharmaceutical formulations and biological fluidsJournal of Pharmaceutical and Biomedical Analysis, 1985
- Fluorometric determination of cephalexin, cephradine, and cephatrizine in biological fluids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979
- Penicillins and cephalosporins from isothiazolylacetic acidsJournal of Medicinal Chemistry, 1968