Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli
- 1 October 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (10) , 3454-3456
- https://doi.org/10.1128/aac.00783-06
Abstract
Weak mutators are common among clinical isolates of Escherichia coli . We show that the relative mutation rate and the “evolvability of fluoroquinolone resistance” are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.Keywords
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