ADRENOCORTICAL RESPONSE TO EPINEPHRINE IN NEUROHYPOPHYSECTOMIZED RATS

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Abstract
In neurohypo-physectomized rats 7 days postoperative, adrenal ascorbic acid depletion following epinephrine was almost entirely abolished. The increase in adrenal and plasma corticosterone was not statistically significant as compared with the resting levels of this group. Neurohypophysectomized rats 14 days postoperative responded to epinephrine as normal rats in corticosterone release, but adrenal ascorbic acid response was slightly reduced. Administration of epinephrine into normal rats caused a marked decrease in the anterior lobe ACTH content, but a slight decrease in the posterior lobe ACTH. Adrenocortical response to exogenous ACTH was of the same extent in both neurohypophysectomized and control rats.