Pathways of post-transcriptional gene regulation in mammalian germ cell development
- 1 July 2003
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 103 (3-4) , 210-216
- https://doi.org/10.1159/000076806
Abstract
Male germ cell development is orchestrated by complex and disparate patterns of gene expression operating in different cell types. The mechanisms of gene expression underlying these have been dissected in the mouse because of its readily available genetics. These analyses have shown that as well as the traditional transcriptional mechanisms, post-transcriptional regulatory pathways of gene expression are essential for mouse spermatogenesis. Proteins essential for germ cell development have been identified which operate at different points throughout the life cycle of RNA from pre-mRNA splicing to translation and RNA decay in the cytoplasm. Recent data suggests that these post-transcriptional pathways respond to environmental cues via signalling pathways.Keywords
This publication has 46 references indexed in Scilit:
- Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAsNature, 2002
- Alternative pre-mRNA splicing and proteome expansion in metazoansNature, 2002
- An extensive network of coupling among gene expression machinesNature, 2002
- TIA-1 and TIAR Activate Splicing of Alternative Exons with Weak 5′ Splice Sites followed by a U-rich Stretch on Their Own Pre-mRNAsJournal of Biological Chemistry, 2001
- mRNA turnoverCurrent Opinion in Cell Biology, 2001
- Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein PhosphataseMolecular and Cellular Biology, 2001
- The Gene for a Variant Form of the Polyadenylation Protein CstF-64 Is on Chromosome 19 and Is Expressed in Pachytene Spermatocytes in MicePublished by Elsevier ,2001
- Identification of an RNA Binding Specificity for the Potential Splicing Factor TLSJournal of Biological Chemistry, 2001
- The STAR/GSG Family Protein rSLM-2 Regulates the Selection of Alternative Splice SitesJournal of Biological Chemistry, 2001
- Pituitary hormone FSH directs the CREM functional switch during spermatogenesisNature, 1993