PERSISTENCE OF IMMUNOGENICITY OF ANTIGEN AFTER UPTAKE BY MACROPHAGES
Open Access
- 1 May 1968
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 127 (5) , 915-926
- https://doi.org/10.1084/jem.127.5.915
Abstract
Peritoneal macrophages were cultured for several hours after uptake of 131I-hemocyanin. The cells degraded most of the 131I-labeled protein within 2–5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.This publication has 21 references indexed in Scilit:
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