Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (10) , 1158-1166
- https://doi.org/10.7164/antibiotics.33.1158
Abstract
Baumycin-negative mutants of S. coeruleorubidus ME130-A4 do not convert daunomycinone to daunomycin and baumycins. They biosynthesize daunomycin from aklavinone and .epsilon.-rhodomycinone, indicating the glycosidation of the aglycone before the synthesis of daunomycinone. The biosynthetic pathway from .epsilon.-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthracyclines, which are presumed to be intermediates.This publication has 9 references indexed in Scilit:
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